News
| September 2024 | Yang Lv has joined the Gu Lab as a PhD student. Tian Le, Yunjia Lv, and Xingru Wu has joined the Gu Lab as master students. Welcome! |
| July 2024 | Read our new paper on General Post-Regulation Strategy of AIEgens’ Photophysical Properties for Intravital Two-Photon Fluorescence Imaging. We proposed a general and efficient post-regulation strategy by simply tuning the ratio of the AIEgens. The fluorescence quantum yield and two-photon absorption cross-section were enhanced by 8.7 and 5.4 times respectively and achieved deep cerebrovascular network imaging with ≈1.10 mm depth and metastatic cancer cell detection with single-cell level resolution. |
| July 2024 | Congratulations on winning the first prize of the 9th National Biomedical Engineering Innovation Design Competition for College Students. The winning project with the title of "Unsupervised virtual staining framework used for label-free in-vivo histopathological examination" innovatively achieved virtual H&E staining of in vivo two-photon autofluorescence images. This project was awarded for its profound significance in clinical pathological diagnosis. Congratulations toNaikun Song and Zhengyuan Pan, and thanks to the rest of the team! |
| July 2024 | Read our new paper on Label-free optical biopsy based on autofluorescence imaging. By optimizing the excitation wavelength, the autofluorescence of FAD and NADH were simultaneously excited to achieve structural imaging based on autofluorescence and robust metabolic imaging baesd on optical redox ratio. Moreover, the relationship and difference among in vitro, ex vivo, and in vivo biopsy were systematically studied, endowing the in vitro and ex vivo biopsy with biological significance. Hepatocellular carcinoma (HCC) was taken as an example to demonstrate the feasibility and superiority. |
| June 2024 | Read our new paper on Highly efficient two-photon photodynamic therapy using light-sheet excitation. We designed and constructed a light-sheet TPE system using a cylindrical lens, which could reach a large TPE domain of 2.6x2.7x0.09 mm in tumor tissue, enabling TPE and generated ROS cover the whole tumor under line-scanning. Outstanding TP-PDT therapeutic performance of 70% tumor growth inhibition rate was achieved under line-scanned light-sheet TPE. Congratulations to Wen Pang and thanks to the rest of the team! |